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The peptide's effects on memory consolidation appear mediated through enhanced hippocampal long-term potentiation (LTP), the neurophysiological basis of memory storage, with Dihexa treatment increasing both the magnitude and persistence of synaptic strengthening

The recommended approach is to discontinue semaglutide, allow a washout period of at least 2-3 weeks (given semaglutide approximately one-week half-life), and then begin retatrutide titration from the standard 1 mg starting dose

This is not necessarily a sign that AOD-9604 has lost effectiveness, but rather reflects the natural progression of fat loss